About the Foundation

The Dr. Paul Duray MD Research Fellowship Endowment Inc., a charitable tax-exempt* foundation, is organized to support medical research into the pathology of human borrelia infections, of which Lyme disease is the best-known example.

The actual extent of Borrelia infections in humans far exceeds the four conditions named “Lyme disease” in the late 1970’s. This was limited to the “Erythema migrans” skin rash, arthritis, cardiac rhythm abnormalities and neurological symptoms of either meningitis or Bell’s palsy.

21st-century physicians know that Borrelia infections are far more complicated than those described by Dr. Allen Steere while he was at Yale University School of Medicine.

The complete clinical picture of Borrelia infections due to the burgdorferi group ( Bbss and Bbsl families) is constantly being added to by patient studies with sophisticated DNA tools. Futhermore, it is now clear that Borrelia species outside of the sensu lato group can cause the same pathology, Borrelia miyamotoi being a prime example.

The model for a highly complex, multi-organ system spirochetal infectious disease (Borreliosis) is the model of Treponema pallidum infection in humans (syphilis).

In borrelial infections, every organ and system of the body may be affected, chronic infections are to be expected, and infections with mixed pathogens including organisms other than spirochetes are regularly diagnosed. As an unfortunate consequence of physicians relying upon a 1970’s simplified model of Lyme disease and poor blood testing tools, Lyme patients may have great difficulty receiving a correct diagnosis in this complex disease.

In Dr Paul Duray’s career, he single-handedly expanded the number of Borrelia illnesses to include:

Borrelia-related Parkinson’s disease;
Borrelia-related intrauterine infections with fetal deaths;
Borrelia muscle diseases, fasciitis and cystitis;
Fatal Adult Respiratory Distress Syndrome (ARDS) due to Borreliosis;
Borrelia-related necrotizing splenitis;
Borrelia hepatitis

He also published many landmark manuscripts which redefined and enlarged the medical and scientifc understanding of spirochetal diseases.

The foundation is currently investigating the links between Borrelia infection and two major neurological diseases: Alzheimer’s Disease and Multiple Sclerosis. Future foci of the foundation may include investigating the role of Borrelia in chronic fatigue syndrome/M.E (myalgic encephalitis) and psychiatric syndromes.

The charitable foundation, named in Dr Paul Duray’s honor, will train young pathologists and scientists in the methods and tools used in Borrelia research. Cutting-edge tools of molecular biology and DNA science will enable researchers to find Borrelia in bodily fluids of living patients as well as in diseased human tissues at autopsy.

We invite you to consider making a tax-deductible* donation to the Foundation to continue the education and specialized training of young investigators who, like Dr. Paul Duray, will devote their careers to Borrelia research and teaching.

Please visit the section Our Work  for more details.

*IRS application for 501c3b Status applied for year 2016

Click here to view curriculum vitae of the organization’s founder and director of research, Dr. Alan B. MacDonald MD, FCAP, FASCP.e