Worm proteins mimic Alpha-Synuclein causing neuro degenerative disease

MacDonald Hypothesis:

Molecular Mimicry in Toxic Worm Proteins and Neurodegenerative Disease

“This image from my Lewy Body Disease research clearly shows a nematode worm in autopsy brain staining globally for Alpha Synuclein (ASN) – like protein which is immunoreactive inside of the worm.A synyc 1

The literature clearly states that ASN proteins are only native to genomes of vertebrates.

Therefore any Alpha-Synuclein immunoreactivities in worm must by definition arise from molecular mimicry of worm-produced proteins which by sheer chance, actually cross-react with antibodies (ABCAM) directed toward human Alpha-Synuclein.
The chance “cross-reaction” is  best reconciled with “C. Elegans LEA residues 351-400″ as a model for comprehension that cross-reacting nematode proteins produce a product toxic to human neurons.

The toxic worm proteins enter the healthy human neuron by synaptic re-uptake , and poison the neuron. There is retrograde movement of the LEA proteins along axons.
In the soma of the doomed neuron, the self-folding nature of the LEA proteins produces the Lewy Body.

Following  the death of the neuron, the  Lewy Body  – free of the neuron’s carcass –  is dumped into the brain as a naked Lewy Body.

Variations on this mechanism  i.e. toxic worm proteins with molecular mimicry to emulate human neuron proteins kill neurons and then dump neuron carcasses in the following diseases:

Pick’s disease, amyotrophic lateral sclerosis, corticobasal degeneration, progressive supranuclear palsy, frontolateral degenerations, multiple systems atrophy (glial cells targeted), Parkinson’s disease, Parkinsonian dementia and less common neurodegenerations in which round bodies  reside inside of diseased neurons.”

This is the MacDonald hypothesis (c) copyright 2016, by. Alan B.MacDonald, MD


Link to my image of a nematode worm in Lewy body dementia decorated with AlphaSynuclein Antibodies (ABCAM). Immunohistochemistry photomicrographs.


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