Glioblastoma Multiforme (GBM) is the most frequently-seen, and the most malignant of the glial tumours, with a median survival in treated patients of just one year.
Typically occurring in the frontal and temporal lobes, GBM may invade adjacent brain areas. It may occur as a primary or secondary brain tumour.
Treatment at present is palliative, consisting of surgical resection, radiotherapy and chemotherapy, though newer approaches are being attempted.
Very little is known about the cause. Genetic factors have been identified, but 99% of cases cannot be linked with a known genetic condition.
Head injury, occupational exposure to toxins and the effects of electromagnetic radiation, including cellphone use, have all been suggested.
This study by Dr. Alan Macdonald demonstrates the DNA of Borrelia burgdorferi in mutliple slides derived from brain biopsy in five of five Glioblastoma Multiforme patients studied, using Fluorescent In Situ Hybridization (FISH) with Molecular Beacon DNA probes highly specific for Borrelia burgdorferi.
Please click here to view micrographs of Borrelia DNA in brain tissue of patients with Glioblastoma Multiforme.